FA Cup winners Arsenal will face League of Ireland aspect Dundalk, Rapid Vienna and Molde in Group B of the 2020-21 Europa League.
Tottenham have been drawn alongside Bulgarian champions Ludogorets, LASK and Royal Antwerp in Group J.
Leicester City will face Braga, AEK Athens and Ukrainian aspect Zorya Luhansk in Group G.
Scottish champions Celtic face a troublesome process in Group H as they tackle AC Milan, Lille and Sparta Prague.
Rangers are in Group D alongside Benfica, Standard Liege and Lech Poznan.
The first three group matches will happen on successive Thursdays from 22 October.
Arsenal certified for the group stage after beating Chelsea to win their report 14th FA Cup in August.
Dundalk beat Faroe Islands membership KI Klaksvik on Thursday to safe their spot, whereas Austrian aspect Rapid Vienna had been eradicated from the Champions League third qualifying spherical.
Tottenham beat Maccabi Haifa within the play-off spherical, whereas Leicester had been crushed to a top-four place on closing day of the 2019-20 Premier League season to finish up within the Europa League.
Celtic beat Bosnian aspect FK Sarajevo on Thursday to qualify and Rangers progressed in opposition to Turkish giants Galatasaray.
Draw in full
Group A: Roma, Young Boys, Cluj, CSKA Sofia
Group B: Arsenal, Rapid Vienna, Molde, Dundalk
Group C: Bayer Leverkusen, Slavia Prague, Hapoel Beer-Sheva, Nice
Group D: Benfica, Standard Liege, Rangers, Lech Poznan
Group E: PSV Eindhoven, PAOK, Granada, Omonoia
Group F: Napoli, Real Sociedad, AZ Alkmaar, Rijeka
Group G: Braga, Leicester, AEK Athens, Zorya Luhansk
Group H: Celtic, Sparta Prague, AC Milan, Lille
Group I: Villarreal, Qarabag, Maccabi Tel-Aviv, Sivasspor
Group J: Tottenham, Ludogorets, LASK, Royal Antwerp
Group Ok: CSKA Moscow, Dinamo Zagreb, Feyenoord, Wolfsberger
Group L: Gent, Red Star, Hoffenheim, Slovan Liberec